Clinical and Coronary Angiographic Profile in Premenopausal Women with Acute Coronary Syndrome Compared With Post Menopausal Women

Background: To study the clinical presentation and coronary angiographic profile in premenopausal women with acute coronary syndrome 2. To compare with the clinical presentation and coronary angiographic profile in postmenopausal women with acute coronary syndrome Method: 43 Patients with Acute Coronary Syndrome admitted in department of cardiology King George Hospital Visakhapatnam , who undergo coronary angiography as a part of investigation . Equal number of post menopausal women with acute coronary syndrome admitted during the same period was taken at random for comparison Results: mean age of premenopausal women in the study is 40.6 ± 5.3 years In postmenopausal group mean age at presentation is is 61.72±6.75 Most common manifestation in ACS in pre menopausal women is chest pain which is present in 95% of patients where as in post menopausal women 88% had chest pain Risk factors: diabetes mellitus is present in 48.8% of cases and 51.1% of controls .Hypertension is present in 44.1%of cases and 65.1% controls . pre and post menopausal women with BMI of more than 24.9 has insignificant correlation with coronary artery disease . LDL value above 130 has significant correlation with ACS. Clinical diagnosis of USA in 32.5% premenopausal women and 39.5% of post menopausal women .Aanterior wall MI in 39.5% of pre menopausal women, 20.9% of post menopausal women .Iinferior wall MI in 11.6% of pre menopausal women and 25.5% of post menopausal women .Coronary angiographic profile revealed SVD in both groups and the difference is insignificant . TVD is found in 34.8% of post menopausal women Conclusions: Most premenopausal women develop acute coronary syndromes in their third and fourth decade close to menopause and often present with chest pain .hypertension is less common in premenopausal women, diabetes is no different in pre and post menopausal women. LDL is significantly lower in pre menopausal women. Smoking is rare in women. No significant difference in BMI exists. Single vessel disease is common in both groups . whereas Triple vessel disease in post menopause women.